Taking information as the most fundamental building block of reality, we discuss what a useful framework this is for viewing all natural and physical phenomena. In building out this framework we touch upon the origin of information, the idea of entropy, the roots of this thinking in thermodynamics, the replication of DNA, development of social networks, quantum behaviour at the micro and macro level, and the very role of indeterminism in the universe. We finish by considering the answer to the ultimate question: where did all of the information in the Universe come from? The ideas challenge our concept of the nature of particles, time, determinism, and of reality itself.